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Lorcaserin

Lorcaserin affects appetite signals in the brain, helping you feel full with smaller meals. Lorcaserin is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Lorcaserin will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure). Keep taking any. How is this medicine (Lorcaserin Tablets) best taken? Use this medicine (lorcaserin tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food. Keep taking this medicine (lorcaserin tablets) as you have been told by your doctor or other health care provider, even if you feel.

Lorcaserin, a selective serotonin 5-HT(2C) receptor agonist, is a weight management agent in clinical development. Lorcaserin N-carbamoyl glucuronidation governs the predominant excretory pathway of lorcaserin in humans. Human UDP-glucuronosyltransferases (UGTs) responsible for lorcaserin N-carbamoyl glucuronidation are identified herein. Lorcaserin is used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and keep from gaining back that weight. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin is in a class of medications called serotonin receptor agonists Caroline Day PhD, FRSB, in Practical Guide to Obesity Medicine, 2018. Lorcaserin. Lorcaserin (BELVIQ) is a US-approved weight loss agent.Lorcaserin (10mg tablet twice daily) was approved in 2012 and a slow release preparation (BELVIQ XR, 20 mg once daily) was approved in July and launched in October 2016. 27 Lorcaserin reduces food intake, possibly via suppressing appetite and increasing. Lorcaserin hydrochloride has a plasma protein binding of approximately 70%. Metabolism. Lorcaserin has extensive hepatic metabolism producing inactive compounds. Lorcaserin sulfamate (M1) is the major metabolite circulating in the plasma, and N-carbamoyl glucuronide lorcaserin (M5) is the major metabolite in urine Lorcaserin(Belviq) generic Lorcaserin is used in adults who are overweight or obese. The drug helps in losing weight. Lorcaserin may be also used in patients who have weight-related medical.

Lorcaserin Uses, Side Effects & Warnings - Drugs

Lorcaserin موانع الاستعمال - Lorcaserin Contraindications in Arabic - in bimariyon se grast hon to Lorcaserin na lein ya savdhani bartein. إذا كنت تعاني من أي من األمراض التالية، يجب عليك عدم تناول Lorcaserin ما لم ينصحك الطبيب بذلك When FDA approved lorcaserin in 2012, we required the drug manufacturer to conduct a randomized, double-blind, placebo-controlled clinical trial to evaluate the risk of cardiovascular problems. Lorcaserin. Lorcaserin (also known as APD356) is the first 5-HT2C agonist approved for chronic weight management since the withdrawal of the 5-HT2C agonist fenfluramine in 1997 due to rare cases of cardiac valvulopathy

Lorcaserin HCl is an appetite-suppressant while orlistat and cetilistat hold back hydrolysis of triglycerides into absorbable fatty acids. The supplement targets the hypothalamic region of the brain that regulates appetite and fullness Lorcaserin is an orally administered medication that promotes weight loss.It is used with diet and exercise in overweight adults with a weight-related medical problem or obese adults to lose weight and keep it off.. Lorcaserin is a serotonin 2C (5-HT2C) receptor agonist. Although the exact mechanism of action is not known, lorcaserin is thought to selectively stimulate 5-HT2C receptors in the. Lorcaserin hydrochloride hemihydrate is a white to off-white powder with solubility in water greater than 400 mg/mL. Each BELVIQ tablet contains 10.4 mg of crystalline lorcaserin hydrochloride hemihydrate, equivalent to 10.0 mg anhydrous lorcaserin hydrochloride, and the following inactive ingredients: silicified microcrystalline cellulose; hydroxypropyl cellulose NF; croscarmellose sodium NF. The FDA approved lorcaserin in 2012, but the agency required the drug manufacturer to conduct a randomized, double-blind, placebo-controlled clinical trial to evaluate the risk of cardiovascular.

Lorcaserin is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who are obese. Lorcaserin is approved for use with a reduced-calorie diet and increased physical activity to help weight loss in adults who are obese or are overweight and have weight-related medical problems Lorcaserin (Handelsname: Belviq resp. Belviq XR) ist ein Arzneistoff aus der Gruppe der Serotoninagonisten, der vorübergehend zur Appetitzügelung zwecks Gewichtsreduktion bei übergewichtigen Patienten in den USA zugelassen war.. Lorcaserin wurde vom US-amerikanischen Pharmaunternehmen Arena Pharmaceuticals entwickelt. Im Mai 2012 wurde das Medikament von der US-amerikanischen.

Lorcaserin Tablets: Indications, Side Effects, Warnings

Lorcaserin C11H14ClN - PubChe

  1. More than 1.9 billion adults worldwide (39%) are overweight; of these adults, more than 650 million (13%) are obese, according to the World Health Organization. In the United States alone, recent s..
  2. The prescription weight control medicine lorcaserin (Belviq, Belviq XR) may increase the risk for cancer, according to the results of a clinical trial assessing the safety of the drug, the U.S.
  3. e.Elle agit par une baisse des apports alimentaires, sans augmentation de la dépense énergétique [4]
  4. Lorcaserin stimulates the serotonin 2c receptor in the brain, including in the hypothalamus - the part of the brain that is associated with mood, appetite and metabolism. The outcome of this action in terms of manifestation is a reduction in appetite
  5. ®」および「BELVIQ XR®」(一般名lorcaserin hydrochloride)の 承認取り下げについて、このたび、米国子会社のエーザイ・インクがプレスリリースを発表いたしました
  6. Lorcaserin bound to human and rat 5-HT(2C) receptors with high affinity (K(i) = 15 +/- 1 nM, 29 +/- 7 nM, respectively), and it was a full agonist for the human 5-HT(2C) receptor in a functional inositol phosphate accumulation assay, with 18- and 104-fold selectivity over 5-HT(2A) and 5-HT(2B) receptors, respectively
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At the time, lorcaserin was FDA-approved as a weight loss drug and being marketed by Eisai under the name Belviq. The market-availability of Belviq (lorcaserin) led researchers to commence a small study of off-label use of Belviq in patients with DS (n=5) to assess impacts on seizure frequency (2) Lorcaserin is used together with diet and exercise to treat obesity. Lorcaserin affects appetite signals in the brain, helping you feel full with smaller meals 11. Lorcaserin الاستعراضات من السمنة 12. ملحق لوركاسيرين 13. شراء Lorcaserin HCL عبر الإنترنت 14. ملخص عن Lorcaserin HCL (Belviq) ادارة الاغذية والعقاقير المعتمدة لتخفيف الوزن المخدرات: Lorcaserin HCL وصف ميت Lorcaserin (Belviq): A selective serotonin 5-HT2C agonist in the treatment of obesity. P T. 2013;38(9):525-34..

Lorcaserin: MedlinePlus Drug Informatio

Pronunciation flashcards for the print, e-book, and pharmacology audiobook Memorizing Pharmacology: A Relaxed Approach. More difficult medication names will. When FDA approved lorcaserin in 2012, we required the drug manufacturer to conduct a randomized, double-blind, placebo-controlled clinical trial to evaluate the risk of cardiovascular problems

Participants will be randomized to receive lorcaserin matching placebo administered as an oral suspension, twice daily for 14 weeks during the core treatment period. Dose will be based on body weight as follows: target dose for participants weighing 10 to <20, 20 to <40, and >=40 kg will be 5, 10, and 20 mg/day respectively Lorcaserin aims to become the next FDA-approved treatment for patients with Dravet syndrome. Developed by Eisai, the selective serotonin 5-HT2C receptor agonist will be used as an adjunctive treatment in the recently initiated phase 3 MOMENTUM 1 clinical study (Study 304; NCT04572243), which will evaluate the agent in patients with Dravet syndrome (DS) and is expected to be completed in. I'm well aware that lorcaserin is a touchy subject for investors. If the drug is approved, it's likely to be a gigantic money-maker just as fenfluramine was. Arena estimates that sales will net $1 billion per year. I believe this is the reason that the lorcaserin entry is being brutally edited Lorcaserin, a selective 5HT2C serotonin receptor agonist, has been refused marketing authorisation in the European Union despite approval in the United States. Clinical evaluation of lorcaserin is based on three placebo-controlled trials, each lasting one year, in a total of about 6000 patients

Lorcaserin - an overview ScienceDirect Topic

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  2. Lorcaserin hydrochloride is a hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid.Used as an anti-obesity drug. It has a role as a serotonergic agonist and an appetite depressant
  3. The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification, was approved by the FDA in 2012 for weight management. It has been marketed in the US as Belviq® since 2013. This article provides a review of the preclinical and clinical pharmacology of lorcaserin, includ
  4. Find all the evidence you need on Lorcaserin via the Trip Database. Helping you find trustworthy answers on Lorcaserin | Latest evidence made eas
  5. e, the fen component of combination medication fen-phen

Lorcaserin DrugBank Onlin

  1. Lorcaserin, marketed under the brand name Belviq is a weight-loss drug developed by Arena Pharmaceuticals.It reduces appetite by activating a type of serotonin receptor known as the 5-HT 2C receptor in a region of the brain called the hypothalamus, which is known to control appetite. It was removed from the market in the United States in 2020 due to its increased risk of cancer
  2. lorcaserin (lor-ca-ser-in) , Belviq (trade name) Classification Therapeutic: weight control agents Pharmacologic: serotonin 2c receptor agonists Pregnancy Category: X Indications In conjunction with a reduced-calorie diet and increased physical activity for chronic weight management in patients with a body mass index (BMI) of ≥30 kg/m2 or 27 kg/m2.
  3. e 2C serotonin receptor, was approved in 2012 as a weight-loss drug to be used in conjunction with calorie restriction and increased physical activity
  4. lorcaserin: ChEBI ID CHEBI:65353: Definition A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group. Stars This entity has been manually annotated by the ChEBI Team
  5. In February, the manufacturer of the weight-loss medication lorcaserin (Belviq, Belviq XR) voluntarily withdrew the drug from the US market at the request of the FDA.This was a result of emerging data showing that people who had taken the drug as part of a large clinical trial had an increased occurrence of cancer five years later
  6. Side Effects. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention
  7. istration (FDA) reported in February 2020 an increased risk of cancer with lorcaserin in the follow‐up of the CAMELLIA‐TIMI 61 trial. This systematic review and meta‐analysis addresses whether lorcaserin is associated with higher incidence of cancer compared with other interventions or no treatment

Lorcaserin Drug Information - Indications, Dosage, Side

Lorcaserin was designed to activate 5-HT2C receptors without significant agonism of the 5-HT2B receptor linked to heart valve toxicity at therapeutic doses. Atthe same time, the agonist activity of lorcaserin at the 5-HT2A receptor, which has been linked to mood and perceptual effects, was minimized All patients who initiated treatment with Lorcaserin during the review period will undergo chart review. The primary endpoint will be weight change in patients on Lorcaserin and average duration of Lorcaserin treatment over time (up to 1 year). Secondary endpoints will include changes in vital signs, liver function, glucose, and lipids Lorcaserin also decreased responding for the discrete cue complex (cue reactivity) previously associated with delivery of oxycodone (i.e., stimulus lights, infusion pump sounds) in both abstinence and extinction-reinstatement models. The selected dose range of lorcaserin (0.25-1 mg/kg) does not overtly alter spontaneous behaviors nor. While Lorcaserin has been labeled a substitute-amphetamine (and, emotionally at least, it's leaving me cold like an amphetamine) I could definitely sleep on it. Like other substitute amphetamines, it's proven near impossible to get an erection. Luckily I have 3 hours until my girlfriend comes over..

Lorcaserin affects chemical signals in the brain that control appetite. Lorcaserin works by helping you feel full with smaller meals. Lorcaserin is used together with diet and exercise to treat obesity. Lorcaserin is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood.. The FDA's decision stems from the review of a 5-year trial designed to evaluate cardiac risk with the weight-loss drug. We believe that the risks of lorcaserin outweigh its benefits, the FDA said

lorcaserin hydrochloride (APD-356) is a serotonin 2C receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adult A trial involving about 12,000 participants over five years found more patients taking Lorcaserin were diagnosed with cancer compared to patients taking placebo, which is an inactive treatment.

We would like to show you a description here but the site won't allow us Lorcaserin is a selective serotonin agonist that was used as a weight loss agent. Lorcaserin was in clinical use for eight years when it was withdrawn because of concerns regarding an excess in cancer risk after long term use. In prelicensure studies and while in clinical use, lorcaserin was not fou The lorcaserin dose is weight-based, so the greater the weight, the greater the dose. There are 3 dosing categories in the trial and there's an opportunity for investigators to do 1 dose increase within the weight category as well. [Patients are] followed for 14 weeks and will use seizure diaries as a way to assess the whole range of seizures.

Belviq (lorcaserin) is a weight loss medication used to help overweight adults with a weight-related medical problem or obese adults to lose weight and keep it off. Common side effects of Belviq include headache, dizziness, fatigue, nausea, dry mouth, constipation, and low blood sugar (hypoglycemia). Do not take Belviq if pregnant. Consult your doctor if breastfeeding Lorcaserin is a prescription medication used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and keep from gaining back that weight. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin is in a class of medications called serotonin receptor agonists Lorcaserin (Belviq) is a selective serotonin 2C agonist labeled for chronic weight management in adults who are obese (body mass index [BMI] ≥ 30 kg per m 2) or who are overweight (BMI ≥ 27 kg. LORCASERIN 637E494O0Z US Previously Marketed Source: LORCASERIN HYDROCHLORIDE by ZYDUS PHARMS USA INC (2019) Source URL:. The Lorcaserin, with its CAS NO 616202-92-7, is a kind of white powder. It has synonyms of (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-, (1R)-. Lorcaserin should be stored in shady and cool warehouse and mainly used as receptor agonist. 2.Properties of Lorcaserin

Lorcaserin (APD-356, trade name upon approval Belviq, expected trade name during development, Lorqess) is a weight-loss drug developed by Arena Pharmaceuticals.It has serotonergic properties and acts as an anorectic. On 22 December 2009 a New Drug Application (NDA) was submitted to the Food and Drug Administration (FDA) in the United States Lorcaserin (616202-92-7), Lorcaserin hydrochloride powder, (R) Lorcaserin hydrochloride (846589-98-8), (R) Lorcaserin hydrochloride (846589-98-8) Kūkulu hua nui i nā mea han

What Is Belviq? Belviq (lorcaserin hydrochloride) is a serotonin 2C receptor agonist indicated for the treatment of chronic weight management in adults with a body mass index of 30 or greater as an addition to a reduced-calorie diet and exercise.Belviq is also approved for use by adults with a BMI of 27 or greater and who have at least one weight-related condition such as high blood pressure. lorcaserin Manufacturers Directory ☆ 3 million global importers and exporters ☆ lorcaserin suppliers, manufacturers, wholesalers, lorcaserin sellers, traders, exporters and distributors from China and around the world at EC21.co Nutratech Orlistol - Carb and Fat Blocker Weight Loss Aid and Diet Pill for Powerful Fat Burning and Appetite Suppression. Excellent for Keto Diet to Get Back into Ketosis Quickly. 60 Count Lorcaserin and Cerebellum · See more » Cerebral cortex The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness Background Lorcaserin is a selective serotonin 2C receptor agonist that could be useful in reducing body weight. Methods In this double-blind clinical trial, we randomly assigned 3182 obese or over..

A Beauty Contest for Obesity Meds in JAMA - ConscienHealthWeight Loss Drug Belviq May Increase Cancer Risk, FDA Reports

Cocrystals of Lorcaserin hydrochloride and an organic diacid, in particular with (+)-di-p-toluoyl-D-tartaric acid; (+)-camphoric acid; and oxalic acid, processes for their preparation, their therapeutical indications, as well as, pharmaceutical compositions containing them. It also relates to a resolution process of lorcaserin which goes through the formation of the cocrystal of (R)-Lorcaserin. Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 QINGDAO SUN TECH INDUSTRIES & TRADING CO., LTD China (Mainland

Lorcaserin was also found to cut the risk of pre-diabetic patients developing diabetes, as well as being linked to small improvements in levels of blood pressure, triglycerides, blood glucose, and. Lorcaserin has 100 fold greater neurologic 5HT-2C affinity over cardiac valve 5HT-2B affinity Well tolerated More specific, and does not appear to carry same valvular heart disease risks as with fenfluramin What is lorcaserin? Lorcaserin is being dubbed as a weight loss pill that works to help suppress appetite by activating a serotonin receptor in the brain, giving the feel of fullness

Lorcaserin - الاستخدامات، الجرعة، الآثار الجانبية، الفوائد

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  2. The Lorcaserin, with its CAS NO 616202-92-7, is a kind of white or kind of white powder. It has synonyms of (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 1H-3-Benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-, (1R)-
  3. LORCASERIN 616202-92-7 Suppliers,provide LORCASERIN 616202-92-7 product and the products related with China (Mainland) LORCASERIN 616202-92-7 coolpharm Ltd China (Mainland) coolpharm Ltd. Home. SellingLeads. Organic Chemicals Pharmaceutical Food Additives. Company Profile. About US.
  4. Cancer Risk Associated with Lorcaserin In early 2020, the FDA requested that the manufacturer of lorcaserin voluntarily withdraw the drug from the market because of a signal of increased cancer ris..
  5. Lorcaserin is a serotonergic drug. The development of potentially life-threatening serotonin syndrome or a Neuroleptic Malignant Syndrome (NMS)-like reaction has been reported during use of serotonergic drugs, particularly when such drugs are combined
  6. received an overall rating of 6 out of 10 stars from 6 reviews. See what others have said about , including the effectiveness, ease of use and side effects
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Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 Chungking Joyinchem Co., Ltd. China (Mainland Lorcaserin ball-and-stick model.png 1,371 × 1,143; 230 KB Lorcaserin Chemical Structure V.1.svg 368 × 239; 10 KB Lorcaserin vs dexfenfluramine.svg 170 × 190; 29 K Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 Changzhou Extraordinary Pharmatech co.,LTD China (Mainland

Video: FDA requests the withdrawal of the weight-loss drug Belviq

Lorcaserin has extensive hepatic metabolism producing inactive compounds. Lorcaserin sulfamate (M1) is the major metabolite circulating in the plasma, and N-carbamoyl glucuronide lorcaserin (M5) is the major metabolite in urine. Other minor metabolites that are both excreted in urine are glucuronide or sulfate conjugates Looking for lorcaserin factory direct sale? You can buy factory price lorcaserin from a great list of reliable China lorcaserin manufacturers, suppliers, traders or plants verified by a third-party inspector. Source with confidence Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 Chemical Co.Ltd China (Mainland The agency approved lorcaserin in 2012 and, as part of that approval, asked Eisai to conduct CAMELLIA-TIMI 61, a randomized, double-blind, placebo-controlled clinical trial to evaluate the risk of cardiovascular events. That trial ultimately found no meaningful difference in rates of major adverse cardiovascular events, but as the FDA notes in.

Long-term Drug Treatment for Obesity: A Systematic and

Lorcaserin - Manufacturer supplier factor

Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 AmoyChem Co.,Ltd China (Mainland) AmoyChem Co.,Ltd. The product range includes Speciality, Petrochemical, APIs and Bio Chemical etc, both labeled and unlabeled chemical raw materials.. Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 Wuhan ZeShanCheng Biomedical Technology Co., Ltd. China (Mainland Alibaba.com에서 최고의 가격으로 고품질의 Lorcaserin 제조사 Lorcaserin 공급자 및 Lorcaserin 제품을 찾

lorcaserin HCL (Belviq): Weight Loss Drug Dosage & Side

Lorcaserin é um composto que atua promovendo a redução do consumo de alimentos e a saciedade, através da ativação de receptores específicos, localizados no hipotálamo. Assim, Lorcaserin ajuda no tratamento de casos de excesso de peso e obesidade Yüksek Kaliteli Lorcaserin Üreticilerini Lorcaserin Tedarikçilerini ve Lorcaserin Ürünleri en iyi fiyatta Alibaba.com'da bulun Lorcaserin vs sibutramina. Como se dijo anteriormente, la lorcaserina induce una sensación de satisfacción mediante la activación de un receptor de serotonina conocido como receptor 5-HT2C que se encuentra en la región del cerebro conocida como hipotálamo

IRLANDA ITALIANA – Aperitivo Italiano in Cork is back!Despite Protests, Arena&#39;s Chances Are Still Slim

Belviq (Lorcaserin Hydrochloride): Uses, Dosage, Side

LORCASERIN 616202-92-7 Suppliers,provide LORCASERIN 616202-92-7 product and the products related with China (Mainland) LORCASERIN 616202-92-7 Nanjing Raymon Biotech Co., Ltd. China (Mainland) Nanjing Raymon Biotech Co., Ltd. Raymon Biotech is a China based globally supplier for organic chemicals, reagents, pharmaceutical intermediates and. Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic BELVIQ - Lorcaserin HCl. 308 likes. Belviq (also known as Lorcaserin HCL) is the first Obesity drug to be approved by FDA in 13 years. It is available in US pharmacies since June 2013 Lorcaserin hydrochloride powder is obtained by reaction of lorcaserin with one equivalent of hydrochloric acid, it is a selective 5-HT2C receptor agonist, In vitro testing lorcaserin hydrochloride shows reasonable selectivity for 5-HT2C over other related targets Lorcaserin 616202-92-7 Suppliers,provide Lorcaserin 616202-92-7 product and the products related with China (Mainland) Lorcaserin 616202-92-7 GIHI CHEMICALS CO.,LIMITED China (Mainland

What Lorcaserin Did for Me MedPage Toda

Belviq, Belviq XR (lorcaserin) dosing, indications

Lorcasérine — Wikipédi

[重症醫學] 急性肺水腫 (acute pulmonary edema) 的治療 - NEJS

Lorcaserin Enters Clinical Trials for Dravet Syndrome

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